Trials under the INSTRuCT Network
To begin with the INSTRuCT network will focus on stroke clinical trials a minimum of 4-5 in the area of acute stroke, secondary prevention and rehabilitation. INSTRUcT will collaborate with professional, industry, academic and funding bodies (within and outside the country) to enhance and increase Indian stroke clinical trials.
The Secondary Prevention By Structured Semi-Interactive Stroke Prevention Package in INDIA (SPRINT INDIA) Trial will be carried out to assess the role of a structured semi-interactive stroke prevention package to reduce the risk of recurrent strokes, myocardial infarction and death in patients with sub-acute stroke after one month.
Enhanced Control of Hypertension and Thrombolysis Stroke study (ENCHANTED) Funded by NHRMC, Australia. (HMSC and ICMR approvals will be obtained). ENCHANTED is an independent, investigator initiated, international collaborative, quasi-factorial randomised controlled trial involving a package of 2 linked comparative treatment arms, which aims to address 4 key questions in patients eligible for thrombolysis in the hyperacute phase of ischaemic stroke.
Approved so far
Early Remote Ischemic Conditioning in Stroke (ERICS) trial funded India Alliance The Wellcome Trust/DBT. Phase 2A trial is being carried out at CMC Ludhiana. Phase 2B of this trial will be carried out under INSTRUcT with permission from ICMR and The Wellcome Trust/DBT at 10 centers.
AyuRvedic TrEatment in the Rehabilitation of IschemicSTrOke Patients in India: A Randomized controllEd trial (RESTORE) for
a) finding out the safety and efficacy of Ayurvedic treatment in the rehabilitation of stroke patients
b) comparing the efficacy of Ayurvedic treatment over conventional physiotherapy in the rehabilitation of stroke patients.